Tandem catalysis in ionic liquids: a recyclable catalytic synthesis of benzofuran derivatives |
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Authors: | Bartolo Gabriele Raffaella Mancuso Giuseppe Salerno |
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Institution: | a Dipartimento di Scienze Farmaceutiche, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy b Dipartimento di Chimica, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy |
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Abstract: | A convenient, recyclable catalytic synthesis of benzofuran-2-acetic esters 2 by sequential Pd(0)-catalyzed deallylation—Pd(II)-catalyzed carbonylative heterocyclization of 1-(2-allyloxyphenyl)-2-yn-1-ols 1 in ionic liquids is presented. Reactions were typically carried out in BmimBF4 as the solvent at 100 °C and under 30 atm of CO, in the presence of catalytic amounts (1 mol %) of PdI2 in conjunction with KI (1 equiv), PPh3 (4 mol %), MeOH (28 equiv), and H2O (2 equiv). The solvent-catalyst system could be recycled several times without appreciable loss of catalytic activity. |
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Keywords: | Benzofurans Carbonylation Ionic Liquids Tandem Catalysis |
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