Synthesis of a proposed biosynthetic intermediate of a marine cyclic ether brevisamide for study on biosynthesis of marine ladder-frame polyethers |
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| Authors: | Tomohiro Shirai Jeffrey LC Wright Masayuki Satake Kazuo Tachibana |
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| Institution: | a Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
b Center for Marine Science, University of North Carolina, Wilmington, Marvin K. Moss Lane, Wilmington, NC 28409, USA |
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| Abstract: | A monocyclic ether alkaloid, brevisamide (1) was isolated from the dinoflagellate Karenia brevis that produces a variety of ladder-frame polyethers. Its proposed biosynthetic intermediate (2) comprising a linear backbone with an E-olefin functionality was synthesized for biosynthetic studies on the marine ladder-frame polyethers. |
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