Gold-catalysed cyclic ether formation from diols |
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Authors: | Xiaolu Jiang |
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Affiliation: | Department of Chemistry, The University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK |
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Abstract: | Gold(I) and (III) salts have been found to be highly effective at the catalysis of ether formation from alcohols. Intramolecular ether formation of a 1,5-diol was also achieved, with a stereoselectivity that indicates that an SN1 mechanism predominates. In an attempt to form a seven-membered ring, a stable 14-membered dimer product was also formed. Attempts to control the diastereoselectivity of the reaction using a chiral anionic counterion did not give products with a high de. |
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Keywords: | Gold Catalysis Cyclisation Diol Ether |
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