Na-promoted aerobic oxidation of alcohols to ketones |
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Authors: | Li-Hong Zhou Xiao-Qi Yu |
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Institution: | a Department of Chemistry, University of Virginia, Charlottesville, VA 22904 4319, USA b Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu 610064, China |
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Abstract: | Aerobic oxidation of a number of diaryl and arylalkyl carbinols to ketones was promoted by Na in THF at room temperature with up to 99% yield. This new oxidation method is also selective with good efficiency for the oxidation of benzylic secondary alcohols but not for a primary alcohol or nonbenzylic secondary alcohols. Under nitrogen, a catalytic amount of Ni or transition metal halides such as CoCl3, FeCl3, and NiCl3 in combination with Na was also found to conduct a dehydrogenation of a secondary alcohol to the corresponding ketone in high yield at room temperature. |
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Keywords: | Na Oxidation Alcohols Ketones Aerobic Anaerobic |
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