A Concise, metathesis based approach to construction of the lepadiformine/cylindricine tricyclic framework |
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| Authors: | Jiwen Zou |
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| Affiliation: | Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131, USA |
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| Abstract: | A tandem dienyne metathesis based strategy has been developed for construction of the core tricyclic framework found in the lepadiformine and cylindricine alkaloids. 2-Pentenyl-2-ethynylpyrollidine acrylamide that serves as the starting material for the key ruthenium carbene catalyzed metathesis process is prepared by using a concise route starting with l-proline. |
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| Keywords: | Ruthenium carbene catalysis Metathesis Pyridinium salt photochemistry |
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