The first catalytic asymmetric total synthesis of ent-hyperforin |
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Authors: | Yohei Shimizu Masakatsu Shibasaki |
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Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan |
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Abstract: | The first catalytic asymmetric total synthesis of ent-hyperforin was described here in detail. Keys to the success were a catalytic asymmetric Diels-Alder reaction, a stereoselective Clasien rearrangement, an intramolecular aldol cyclization, and a vinylogous Pummerer rearrangement. Along with the successful synthetic route, several attempted approaches toward the construction of bicyclo3.3.1] core and the C2 oxidation were discussed. |
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Keywords: | KGSZHKRKHXOAMG-QFBSZDFWSA-N |
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