Facile preparation of alkoxybenzoxazoles via direct SNAr on the benzoxazole ring |
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| Authors: | Hervé Germain,Michel Vautier,Nicolas Warin |
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| Affiliation: | AstraZeneca, Centre de Recherches, Z.I. la Pompelle, BP1050, 51689 Reims Cedex 2, France |
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| Abstract: | The synthesis of alkoxybenzoxazoles is in general quite challenging. During our investigation, we discovered that C-4 and C-7 fluoro precursors undergo SNAr with alkoxides affording moderate to excellent yields of substituted product. |
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| Keywords: | Direct SNAr Un-activated fluorides |
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