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Formal total synthesis of ottelione using iridium-catalyzed oxidative desymmetrization |
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| Authors: | Takeyuki Suzuki Kazem Ghozati Tadashi Katoh |
| Affiliation: | a The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan b Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan |
| Abstract: | A catalytic asymmetric synthesis of a key intermediate for ottelione has been achieved using oxidative desymmetrization as the critical step. This oxidative desymmetrization was efficiently promoted by an iridium diamine complex to give the desired hydroxy ketone in >99% ee and 60% yield. |
| Keywords: | Iridium Oxidative desymmetrization Ottelione meso diol Hydrogen-transfer reaction |
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