Boric acid catalyzed convenient synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines in aqueous media |
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| Authors: | Pravin V. Shinde |
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| Affiliation: | Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, India |
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| Abstract: | A one-pot three-component condensation of an aldehyde, malononitrile, and thiophenol has been achieved by conventional and ultrasound method. The reaction has been catalyzed by boric acid in aqueous medium. This protocol afforded corresponding 2-amino-3,5-dicarbonitrile-6-thio-pyridines in shorter reaction times and high yields with the green aspects by avoiding toxic catalysts and solvents. |
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| Keywords: | Aldehyde Malononitrile Thiophenol Boric acid Aqueous media Ultrasonication |
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