A xanthate-based free radical approach to defucogilvocarcin M |
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| Authors: | Omar Cortezano-Arellano |
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| Affiliation: | Instituto de Química, Universidad Nacional Autónoma de México. Circuito Exterior s/n, Ciudad Universitaria, 04510, México, D.F., Mexico |
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| Abstract: | A formal total synthesis of the aglycon of gilvocarcin M is described. The synthesis is based on the construction of the key naphthalene 7 via a free radical addition-cyclization protocol followed by aromatization of the resulting α-tetralone. This highly functionalized aromatic system is coupled to the corresponding acid chloride 6 to afford ester 4, which by treatment with a catalytic amount of palladium (0) produced defucogilvocarcin M (1a). |
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