a The Department of Chemistry, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK b ALS, Berkeley Laboratory, 1 Cyclotron Road, MS2-400, Berkeley, CA 94720, USA
Abstract:
The diesterification and selective mono and dialkylation of carbocyclic analogues of Tröger’s base with pyridyl groups has been achieved in high yield and good selectivity giving access to a novel range of cleft molecules capable of binding events. Reaction conditions for the selective functionalization of this carbocyclic cleft molecule are discussed as well as the solid state structures of these newly synthesized ligands.