A new, efficient, and inexpensive copper(II)/salicylic acid complex catalyzed Sonogashira-type cross-coupling of haloarenes and iodoheteroarenes with terminal alkynes |
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| Authors: | Horung-Jyh Chen |
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| Institution: | Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan |
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| Abstract: | A new, efficient, and inexpensive CuCl2/salicylic acid catalytic system has been developed to catalyze Sonogashira-type cross-coupling of haloarenes and iodoheteroarenes with terminal alkynes under mild reaction conditions to afford the corresponding coupling products in 18-95% yields. The role of salicylic acid might act as a bidentate O,O-donor ligand to activate the catalytic reactivity of copper chloride in coupling reactions was also briefly discussed. |
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| Keywords: | Salicylic acid Sonogashira-type cross-coupling reaction Copper chloride Haloarenes Terminal alkynes |
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