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A ‘click chemistry’ approach to the efficient synthesis of modified nucleosides and oligonucleotides for PET imaging |
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| Authors: | Damien James Eric Amigues Christiane Vitry Magali Szlosek-Pinaud Eric Fouquet |
| Institution: | a Université de Bordeaux,UMR CNRS 5255, Institut des Sciences Moléculaires, 351 Cours de la Libération, Talence F-33405, France b Université Paul Sabatier, UMR CNRS 5068, LSPCMIB, 118 rte de Narbonne, Toulouse F-31062, France c Université de Bordeaux, UMR CNRS 5231, LIMF, 146 rue Léo Saignat, Bordeaux F-33076, France |
| Abstract: | Different thymidine derivatives bearing either an iodoaryl moiety at the 5′ position or a dialkylsilyl group at the 3′ position have been efficiently synthesized as precursors for carbon-11 or fluorine-18 labeling, respectively. Furthermore, iodoarylated thymidine derivatives have been incorporated into oligonucleotides giving an original way to label them with carbon-11. |
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