A chemoenzymatic and enantioselective total synthesis of the resorcylic acid lactone L-783,290, the trans-isomer of L-783,277 |
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| Authors: | Andrew Lin |
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| Affiliation: | Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia |
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| Abstract: | The structure, 5, assigned to the resorcylic acid lactone L-783,290 has been prepared for the first time and in a modular fashion using a Heck reaction to link the readily available fragments 8 and 14. Chemoenzymatic methods were used to prepare the latter fragment, in enantiopure form, from chlorobenzene. |
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| Keywords: | Chemoenzymatic Heck reaction Resorcylic acid lactones Ring-closing metathesis Synthesis |
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