A chemoenzymatic and enantioselective total synthesis of the resorcylic acid lactone L-783,290, the trans-isomer of L-783,277 |
| |
| Authors: | Andrew Lin |
| |
| Institution: | Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia |
| |
| Abstract: | The structure, 5, assigned to the resorcylic acid lactone L-783,290 has been prepared for the first time and in a modular fashion using a Heck reaction to link the readily available fragments 8 and 14. Chemoenzymatic methods were used to prepare the latter fragment, in enantiopure form, from chlorobenzene. |
| |
| Keywords: | Chemoenzymatic Heck reaction Resorcylic acid lactones Ring-closing metathesis Synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
