Highly enantioselective Michael addition of aldehydes to nitroolefins catalyzed by primary amine thiourea organocatalysts |
| |
| Authors: | Jia-Rong Chen |
| |
| Affiliation: | Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China |
| |
| Abstract: | Asymmetric Michael addition reactions of aldehydes to nitroolefins have been successfully initiated by a series of primary amine thiourea bifunctional catalysts, with high enantioselectivities (90-98% ee) and excellent yields (80-96%). The privileged quinine scaffold was found to be essential to the reaction efficiency and enantioselectivity. |
| |
| Keywords: | Organocatalysis Michael addition Amine thiourea Nitroolefin |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
