The first example of the cascade assembly of a spirocyclopropane structure: direct transformation of benzylidenemalononitriles and N,N′-dialkylbarbituric acids into substituted 2-aryl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitriles |
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| Authors: | Michail N Elinson Anatolii N Vereshchagin Tatiana A Zaimovskaya Gennady I Nikishin |
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| Institution: | a N. D. Zelinsky Institute of Organic Chemistry, Leninsky Prospect 47, 119991 Moscow, Russia
b A. V. Topchiev Institute of Petrochemical Synthesis, Leninsky Prospect 29, 119991 Moscow, Russia |
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| Abstract: | The direct formation of substituted 2-aryl-4,6,8-trioxo-5,7-diazaspiro2.5]octane-1,1-dicarbonitriles in 75-95% yields from benzylidenemalononitriles and N,N′-dialkylbarbituric acids is described. |
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| Keywords: | Benzylidenemalononitriles Barbituric acids Cyclopropane formation 5 7-Diazaspiro[2 5]octane |
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