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A novel route to 2,4-dianilino-substituted pyrimidines |
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| Authors: | Ruben Leenders Jan Heeres Paul Lewi |
| Affiliation: | a Mercachem BV, Kerkenbos 10-13, 6546 BB Nijmegen, The Netherlands b Janssen Research Foundation, Center for Molecular Design, Antwerpsesteenweg 37, B-2350 Vosselaar, Belgium c Johnson and Johnson Pharmaceutical Research and Development, Medicinal Chemistry Department, Campus de Maigremont BP315, F-27106 Val de Reuil Cedex, France |
| Abstract: | A method is described to couple sterically-hindered electron-poor anilines to the 4-position of the pyrimidine core using a pyrimidine-2,4-bis(trifluoromethanesulfonate). |
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