Novel access to 1-substituted-benzimidazoles via benzotriazole-mediated synthesis |
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Authors: | Augusto Rivera,Mauricio Maldonado,Jaime Rí os-Motta,Miguel Angel Navarro,Diego Gonzá lez-Salas |
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Affiliation: | Departamento de Química, Universidad Nacional de Colombia, Ciudad Universitaria, Carrera 30 No. 45-03, Bogotá DC, Colombia |
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Abstract: | A one-pot good-yielding synthesis of 1-(alcoxymethyl)-1H-benzimidazoles and 1-((1H-benzimidazol-1-yl)methyl)-1H-benzotriazole from N1,N2-bis((1H-benzotriazol-1-yl)methyl)benzene-1,2-diamine (3) and alcohols is described. The synthesis of 3 from macrocyclic aminal 6H,13H-5:12,7:14-dimethanedibenzo-[d,i][1,3,6,8]tetraazecine (DMDBTA, 1) and benzotriazole is also described. Both these methods are simple, isolation of the products from the reaction mixtures is easy, and the yields are good. |
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