Synthesis of pyrimido[6,1-a]isoquinolines via a one-pot, four-component reaction |
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| Authors: | Abdolali Alizadeh Atieh Rezvanian |
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| Affiliation: | a Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran 14115, Iran
b Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China |
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| Abstract: | An efficient one-pot synthesis of pyrimido[6,1-a]isoquinoline-1-carboxylate derivatives is described. This involves the four-component reaction between primary amines, alkyl acetoacetates, isoquinoline and trichloromethylchloroformate (diphosgene) under mild conditions at ambient temperature. |
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| Keywords: | Trichloromethylchloroformate Alkyl acetoacetates Enaminone Pyrimido-isoquinoline Four-component reaction |
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