Ligand-free, atom-efficient Suzuki-Miyaura type cross-coupling reactions at room temperature |
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Authors: | Wen-Jun Zhou Jin-Xian Wang Zhi-Rong Gao |
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Institution: | a Institute of Chemistry, Department of Chemistry, Northwest Normal University, 967 Anning Road (E), Lanzhou 730070, PR China b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China |
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Abstract: | The atom-efficient cross-coupling reaction of sodium tetraarylborates with aryl iodides and bromides was reported. The reaction can be performed directly using a catalytic system composed of palladium chloride, sodium carbonate and methanol (PdCl2/Na2CO3/MeOH) under heat-free conditions at room temperature in an open air conditions. The reactions carried out in an atom-efficient way as 4 equiv of aryl halides coupled effectively with 1 equiv of sodium tetraarylborates to furnish 4 equiv of the corresponding functionalized biaryls in good to excellent yields. |
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