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Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species |
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| Authors: | Magda Darren Gerasimchuk Nikolay Lecane Philip Miller Richard A Biaglow John E Sessler Jonathan L |
| Institution: | Pharmacyclics, Inc., 995 E. Arques Avenue, Sunnyvale, CA 94085, USA. dmagda@pcyc.com |
| Abstract: | Motexafin gadolinium (MGd) oxidizes ascorbate, in neutral buffer and in cell culture, forming reactive oxygen species and a coordination polymer with oxalate. |
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