Conductometric titration of pindolol and propranolol using ammonium reineckate and potassium tetracyanonickelate

A simple and sensitive conductometric method for the determination of 2–24 mg of pindolol and propranolol hydrochlorides using ammonium reineckate and potassium tetracyanonickelate in an ethanol-water mixture is described. The effect of the solvent ratio, reagent concentration, time and temperature on the shape of the titration curve is studied. Statistical treatment of the experimental results indicates that the method is precise and accurate. The accuracy of the method is indicated by the excellent recovery (98.2–101.2%) and the precision is supported by the low standard deviation value < 0.10. The sensitivity of the proposed method is discussed and the results are compared with the pharmacopoeial non-aqueous titration method.