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Kinetic resolution of racemic pyrrolidine-2,5-diones using chiral oxazaborolidine catalysts |
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| Authors: | Barker Mike D Dixon Rachel A Jones Simon Marsh Barrie J |
| Institution: | GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK SG1 2NY. |
| Abstract: | Kinetic resolution of racemic C-3 substituted pyrrolidine-2,5-diones has been achieved for the first time using highly efficient oxazaborolidine catalysts derived from cis-1-amino-indan-2-ol. |
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