Pt(II)-catalyzed synthesis of 1,2-dihydropyridines from aziridinyl propargylic esters |
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| Authors: | Motamed Massoud Bunnelle Eric M Singaram Surendra W Sarpong Richmond |
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| Affiliation: | Department of Chemistry, University of California, Berkeley, California 94720, USA. |
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| Abstract: | Pt(II)-catalyzed cycloisomerization of aziridinyl propargylic esters affords 1,2-dihydropyridines with regiodefined installation of substituents. A mild conversion of the 1,2-dihydropyridines to the corresponding substituted pyridines as well as chirality retention from the aziridinyl propargylic ester substrates have been demonstrated. |
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