Resonant infrared pulsed laser deposition of thin biodegradable polymer films |
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| Authors: | DM Bubb B Toftmann RF Haglund Jr JS Horwitz MR Papantonakis RA McGill PW Wu DB Chrisey |
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| Institution: | (1) Naval Research Laboratory, Washington, DC 20375, USA, US;(2) Riso National Laboratory, Roskilde, Denmark, DK;(3) Department of Physics and Astronomy and W.M. Keck Free Electron Laser Laboratory, Vanderbilt University, 6301 Stevenson Laboratory, Nashville, TN 37235, USA, US |
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| Abstract: | Thin films of the biodegradable polymer poly(DL-lactide-co-glycolide) (PLGA) were deposited using resonant infrared pulsed
laser deposition (RIR-PLD). The output of a free-electron laser was focused onto a solid target of the polymer, and the films
were deposited using 2.90 (resonant with O-H stretch) and 3.40 (C-H) μm light at macropulse fluences of 7.8 and 6.7 J/cm2, respectively. Under these conditions, a 0.5-μm thick film can be grown in less than 5 min. Film structure was determined
from infrared absorbance measurements and gel permeation chromatography (GPC). While the infrared absorbance spectrum of the
films is nearly identical with that of the native polymer, the average molecular weight of the films is a little less than
half that of the starting material. Potential strategies for defeating this mass change are discussed.
Received: 22 August 2001 / Accepted: 23 August 2001 / Published online: 17 October 2001 |
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| Keywords: | PACS: 61 41 +e 78 30 -j 81 05 Lg 81 15 Fg |
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