Efficient and green synthesis of tetrasubstituted pyrroles promoted by task-specific basic ionic liquids as catalyst in aqueous media |
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| Authors: | Issa Yavari Elaheh Kowsari |
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| Affiliation: | (1) Chemistry Department, Science & Research Campus, Islamic Azad University, Ponak, Tehran, Iran;(2) Chemistry Department, Tarbiat Modarres University, 14115–175 Tehran, Iran |
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| Abstract: | Synthesis of tetrasubstituted pyrroles by the three-component condensation reaction of acid chlorides, dialkyl acetylenedicarboxylates, and amino acids in the presence of various room-temperature ionic liquids (RTILs) as catalysts in water is reported. Among the ionic liquids used, the basic functionalized ionic liquid, butyl methyl imidazolium hydroxide [bmim]OH, was the most effective catalyst. The influence of reaction temperature, reaction time, and amount of ionic liquid on the reaction was investigated. The [bmim]OH/H2O catalyst system could be reused for at least five recycles without appreciable loss of efficiency. |
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