Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation |
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| Authors: | Shen-Ting Zhao Ming Chen Shu-Ji Li Ming-Hai Zhang Bo-Xing Li Manas Das Jonathan C Bean Ji-Ming Kong Xin-Hong Zhu Tian-Ming Gao |
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| Affiliation: | (1) Department of Neurobiology, Southern Medical University, Guangzhou, PR China;(2) Department of Human Anatomy and Cell Science, University of Manitoba Faculty of Medicine, Winnipeg, Man., Canada;(3) Department of Neuroscience, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, USA |
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| Abstract: | Background Caspase-independent apoptotic pathways are suggested as a mechanism for the delayed neuronal death following ischemic insult. However, the underlying signalling mechanisms are largely unknown. Recent studies imply the involvement of several mitochondrial proteins, including endonuclease G (EndoG) and Bcl-2/adenovirus E1B 19 kDa-interacting protein (BNIP3), in the pathway of non-neuronal cells. |
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