Futalosine and its derivatives, new nucleoside analogs |
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| Authors: | Hosokawa N Naganawa H Kasahara T Hattori S Hamada M Takeuchi T Yamamoto S Tsuchiya K S Hori M |
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| Institution: | Institute of Microbial Chemistry, Shinagawa-ku, Tokyo, Japan. |
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| Abstract: | Futalosine, a new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. Some chemical derivatives of futalosine were prepared. 6-O-Methylfutalosine methylester inhibited growth of HeLa-S3 cells in vitro (IC50 = 19.5 micrograms/ml) in contrast to the weak activity of futalosine. 6-O-Methylfutalosine methylester at concentrations higher than 10 micrograms/ml inhibited incorporation of 3H-TdR and 3H-UR but not 3H-Leu in the acid-soluble fractions of HeLa-S3 cells. |
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