Biosynthesis of chiral methyl ketone cyanohydrins catalyzed by oxynitrilase in Chaenomeles speciosa seed meal |
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| Authors: | Fang Fang Ai-guo Ji and Zhao-li Meng |
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| Institution: | (1) School of Pharmaceutical Science, Shandong University, Jinan, 250012, P. R. of China;(2) College of Pharmacy, Anhui College of Traditional Chinese Medicine, Hefei, 230031, P. R. of China |
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| Abstract: | The oxynitrilase in Chaenomeles Speciosa seed meal was used as the biocatalyst to synthesize a series of chiral methyl ketone cyanohydrins with satisfactory conversion
and conspicuous enantiomeric excess. The optimized reaction conditions including the organic solvent, the ratio of biphasic
solvents as well as the pH of the reaction system were investigated. |
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| Keywords: | Oxynitrilase biotransformation enantioselectivity hydrocyanation |
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