Asymmetric allylic alkylation of isatin-derived morita-baylis-hillman carbonates with nitroalkanes |
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Authors: | Guo-Ying Chen Fangrui Zhong Yixin Lu |
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Affiliation: | Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore , 3 Science Drive 3, Republic of Singapore, 117543. |
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Abstract: | A stereoselective allylic alkylation of isatin-derived Morita-Baylis-Hillman (MBH) carbonates with nitroalkanes has been developed. In the presence of 10 mol % β-isocupreidine (β-ICD), 3,3'-disubstituted oxindoles were prepared with moderate diastereoselectivities and excellent enantioselectivities. |
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