Formal syntheses of naturally occurring welwitindolinones |
| |
| Authors: | Tsung-Hao Fu William T McElroy Mariam Shamszad Stephen F Martin |
| |
| Institution: | Department of Chemistry and Biochemistry, The University of Texas at Austin , Austin, Texas 78712, United States. |
| |
| Abstract: | The formal syntheses of N-methylwelwitindolinone C isothiocyanate, N-methylwelwitindolinone C isonitrile, N-methylwelwitindolinone D isonitrile, 3-hydroxy-N-methylwelwitindolinone C isothiocyanate, and 3-hydroxy-N-methylwelwitindolinone C isonitrile are reported. The synthesis features several novel processes, including a Lewis acid mediated coupling between a benzylic-type heteroaromatic alcohol and a highly functionalized silyl ketene acetal, an intramolecular enolate arylation, and a regioselective, Pd(0)-catalyzed π-allylic cyclization of a γ-benzoyloxy enone moiety that is revealed by unmasking a furan ring. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
