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Novel route for the synthesis of structurally diverse pyrrolo[2,1-a]isoquinoline in aqueous micellar medium
Authors:Subhendu NaskarMaitreyee Banerjee  Abhijit HazraShyamal Mondal  Arindam MaityRupankar Paira  Krishnendu B. SahuPritam Saha  Sukdeb BanerjeeNirup B. Mondal
Affiliation:Department of Chemistry, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India
Abstract:A high yielding environmentally benign protocol has been developed for the synthesis of pyrrolo[2,1-a]isoquinoline using chromone-3-carboxaldehyde, isoquinoline and phenacyl bromide/bromoacetic acid ester as reagents in aqueous micellar medium. The method is operationally simple and more effective compared to the previous methods in terms of the yield of the products as well as the reaction time.
Keywords:Pyrrolo[2,1-a]isoquinoline   Micelle   Chromone-3-carboxaldehyde   1,3-Dipolar cycloaddition reaction   Reactions in water
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