| 电压门控钠离子通道:律动生命乐章的主音符 |
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| 引用本文： | 刘志睿,何慧琼,吉永华.电压门控钠离子通道:律动生命乐章的主音符[J].上海大学学报(自然科学版),2011,17(4):573-580. |
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| 作者姓名： | 刘志睿 何慧琼 吉永华 |
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| 作者单位： | 上海大学生命科学学院,上海,200444 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)资助项目(1999054001,2006CB500801,2010CB529806); 国家自然科学基金资助项目(30270428,30370446,30772554); 国家杰出青年基金资助项目(39625010); 上海市科委自然科学重点基金资助项目(08JC1409500); 上海市教委重点学科《分子生理学》建设资助项目 |
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| 摘 要： | 生命个体传递神经冲动时扩布的电位变化过程以动作电位发放形式为特质表征.电压门控钠离子通道 (voltage-gated sodium channels,VGSCs)是形成动作电位的核心蛋白构件,在细胞的电兴奋产生和律动中起主角作用.VGSCs决定神经元细胞的兴奋性以及从突触输入到轴突输出的信号传导过程.VGSCs也是众...
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| 关 键 词： | 动作电位 电压门控钠离子通道 神经毒素 |
Voltage-Gated Sodium Channels:A Root Note Dancing in Music of Life |
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| LIU Zhi-rui,HE Hui-qiong,JI Yong-hua.Voltage-Gated Sodium Channels:A Root Note Dancing in Music of Life[J].Journal of Shanghai University(Natural Science),2011,17(4):573-580. |
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| Authors: | LIU Zhi-rui HE Hui-qiong JI Yong-hua |
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| Institution: | LIU Zhi-rui,HE Hui-qiong,JI Yong-hua (School of Life Sciences,Shanghai University,Shanghai 200444,China) |
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| Abstract: | Action potential is a form of electric signaling responsible for conducting neural firing in organisms.Voltage-gated sodium channels(VGSCs) are key molecules contributing to the initiation of action potential,playing an indispensable role in electric excitation and firing neurons.Briefly,the overall excitory activities and signalling input/output process of synaptic transmission in neurons mostly depends on VGSCs.Meanwhile,VGSCs are targets of numerous natural neurotoxns or synthesize compounds.By blocking ... |
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| Keywords: | action potential voltage-gated sodium channels(VGSCs) neurotoxin |
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