Trichlorosilyl triflate for enantioselective direct-type aldol reaction with chiral phosphine oxide |
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| Authors: | Shunsuke Kotani Shohei AokiMasaharu Sugiura Makoto Nakajima |
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| Affiliation: | a Priority Organization for Innovation and Excellence, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, Japan
b Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, Japan |
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| Abstract: | Trichlorosilyl triflate, in the presence of a chiral Lewis base catalyst, provides an effective method for the enantioselective direct-type aldol reaction of aldehydes and ketones. A chiral Lewis base induces both the production and activation of trichlorosilyl enol ether, yielding an aldol product in good yield and with high diastereo- and enantioselectivities. |
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| Keywords: | Aldol reaction Enantioselective catalysis Lewis base Phosphine oxide Trichlorosilyl triflate |
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