杂多酸环戊二烯钒衍生物的合成、谱学性质及抗肿瘤活性

合成了杂多酸环戊二烯钒衍生物Bu₄N]₄(CpV)PW₁₁O₃₉](1)，Bu₄N]₄H(CpV)SiW₁₁O₃₉](2)和Bu₄N]₄A-β-(η5-CpV)SiW₉V₃O₄₀](3)，并通过元素分析、IR、51V和183W NMR谱进行了结构表征。结果表明配合物(1)和(2)为结合型有机金属配合物，(3)为支撑型杂多酸有机金属配合物。体外抗肿瘤活性研究表明化合物(1)对HL-60和B₁₆均具有一定的抑制作用。

Synthesis, Spectroscopic Characterization and Antitumoral Activities of Cyclopentadienylvanadium Derivatives of Polyoxotungstates

Cyclopentadienylvanadium derivatives of polyoxotungstates Bu₄N]₄(CpV)PW₁₁O₃₉] (1), Bu₄N]₄H(CpV)SiW₁₁O₃₉] (2) and Bu₄N]₄A-β-(η5-CpV)SiW₉V₃O₄₀] (3) were synthesized, and characterized by elemental analysis, IR, 51V and 183W NMR spectroscopy. Experiment results indicate that (1) and (2) are polyoxometalate-incorporated organometallic complexes, and (3) is a polyoxometalate supported organometallic complex. Antitumoral activities were examined by MTT method. Experiment results indicate that the title complexes did exhibit to a certainty antitumor activity for HL-60 and B₁₆.