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| 新型光动力学疗法光敏剂5-ALA-GNPs的制备及其光谱分析 | |
| 引用本文： | 姚翠萍,王斯佳,杨洋,韩玉龙,许皓,曾维惠,张镇西. 新型光动力学疗法光敏剂5-ALA-GNPs的制备及其光谱分析[J]. 光谱学与光谱分析, 2012, 32(9): 2519-2522. DOI: 10.3964/j.issn.1000-0593(2012)09-2519-04 |
| 作者姓名： | 姚翠萍 王斯佳 杨洋 韩玉龙 许皓 曾维惠 张镇西 |
| 作者单位： | 1. 生物医学信息工程教育部重点实验室，西安交通大学生命科学与技术学院，陕西 西安 710049 2. 西安交通大学生物医学工程与生物力学研究中心，陕西 西安 710049 3. 西安交通大学医学院第二附属医院皮肤科，陕西 西安 710061 |
| 基金项目： | 国家自然科学基金项目，西安交通大学基本科研业务 |
| 摘 要： | 通过聚二烯丙基二甲基胺盐酸盐和氯金酸制备阳离子纳米金，将纳米金和5-氨基乙酰丙酸(5-aminolevulinic acid, 5-ALA)通过静电吸附作用有效结合得到新型光敏剂。应用共振瑞利散射光谱, 紫外-可见吸收光谱, 透射电镜和激光散射等方法对其进行了表征。结果表明通过这种方法纳米金与5-ALA可以有效结合。这种新型光敏剂对提高光动力学疗法临床疗效具有重要指导意义。 |
| 关 键 词： | 5-氨基乙酰丙酸 纳米金 光动力学疗法 |
| 收稿时间： | 2012-04-07 |
New Photosensitiser 5-ALA-GNPs for Photodynamic Therapy and Its Spectral Analysis |
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| YAO Cui-ping , WANG Si-jia , YANG Yang , HAN Yu-long , XU Hao , ZENG Wei-hui , ZHANG Zhen-xi. New Photosensitiser 5-ALA-GNPs for Photodynamic Therapy and Its Spectral Analysis[J]. Spectroscopy and Spectral Analysis, 2012, 32(9): 2519-2522. DOI: 10.3964/j.issn.1000-0593(2012)09-2519-04 | |
| Authors: | YAO Cui-ping WANG Si-jia YANG Yang HAN Yu-long XU Hao ZENG Wei-hui ZHANG Zhen-xi |
| Affiliation: | 1. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China2. Biomedical Engineering and Biomechanics Center, School of Aerospace, Xi’an Jiaotong University, Xi’an 710049, China3. Department of Dermatology, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710061, China |
| Abstract: | A novel strategy by means of poly diallyl dimethylammonium chloride (PDDA) was used to make highly mono-dispersed positively charged gold nanoparticles, and 5-ALA was immobilized onto the gold nanoparticles through electrostatic interaction. The conjugation of 5-aminolevulinic acid (5-ALA) and gold nanopartilces were characterized by the integrated tools of resonance Rayleigh scattering (RRS), UV-Vis absorption spectra, transmission electron microscopy (TEM) and laser light scattering. The results demonstrated that 5-ALA can be attached onto positively charged gold nanoparticles. This new photosensitizer is significant for enhancing PDT efficacy clinically. |
| Keywords: | 5-ALA Gold nanoparticles Photodynamic therapy |
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