Total synthesis of (+)-peloruside A |
| |
Authors: | Jin Meizhong Taylor Richard E |
| |
Institution: | Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556-5670, USA. |
| |
Abstract: | reaction: see text] A total synthesis of (+)-peloruside A has been successfully achieved. The strategy was highlighted by a late stage aldol coupling of two complex fragments followed by an intramolecular hemi-ketal cyclization, a MOM group participated epoxide ring fragmentation reaction, and a highly selective methylation. This convergent route allows access to rationally designed analogues. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|