Synthesis of amino acid derived enaminones via Wolff rearrangement using vinylogous amides as carbon nucleophiles |
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| Authors: | Seki Hajime Georg Gunda I |
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| Affiliation: | Department of Chemistry, Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, USA. |
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| Abstract: | Cyclic enaminones were synthesized in high yields from amino acids in two steps via Wolff rearrangement. The cyclization represents a rare 6-exo-dig cyclization involving a ketene as an electrophile. No racemization was observed during this reaction. |
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