醇钠催化苯甲醛合成苯甲酸苄酯——介绍一个探索性有机化学实验

Self-Condensation of Benzaldehyde to Benzyl Benzoate over Sodium Benzyloxide

To cultivate students' innovation ability,we designed the synthetic method of benzyl benzoate as an organic chemistry laboratory experiment.Benzyl benzoate was directly synthesized from benzaldehyde in the presence of a sodium benzyloxide via the Tishchenko reaction.The experimental conditions are optimized with a benzaldehyde to sodium benzyloxide mole ratio of 33:1 and a 50-60℃ reaction temperature for 1 h.A yield up to 69% was achieved with the purity higher than 99%.The experimental results show that the process is in accordance with the requirements of organic chemistry laboratory teaching.