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| 芳基乙酮酸乙酯的合成新方法 | |
| 引用本文： | 向纪明,陈久存,李宝林.芳基乙酮酸乙酯的合成新方法[J].有机化学,2009,12(3):392-395. |
| 作者姓名： | 向纪明 陈久存 李宝林 |
| 作者单位： | 1. 陕西师范大学化学与材料学院教育部药用植物资源与天然药物化学重点实验室西安710062安康学院化学系,安康,725000 2. 安康学院化学系,安康,725000 3. 陕西师范大学化学与材料学院教育部药用植物资源与天然药物化学重点实验室,西安,710062 |
| 基金项目： | 教育部科学技术研究重点项目，陕两省教育厅资助项目 |
| 摘 要： | 以芳烃和草酰氯单乙酯为原料, 采用Friedel-Crafts酰基化反应合成了8种芳基乙酮酸乙酯, 用IR, 1H NMR, 元素分析确认了合成化合物结构, 并用高效液相色谱法分析了反应的选择性. 此合成方法具有反应条件温和、操作简单、产率高的特点. |
| 关 键 词： | 芳基乙酮酸乙酯 酰基化反应 合成 |
| 收稿时间： | 2007-10-31 |
| 修稿时间： | 2008-1-28 |
A New Way to Synthesis of Ethyl Arylglyoxylates |
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| XIANG Ji-ming,CHEN Jiu-cun,LI Bao-lin.A New Way to Synthesis of Ethyl Arylglyoxylates[J].Chinese Journal of Organic Chemistry,2009,12(3):392-395. | |
| Authors: | XIANG Ji-ming CHEN Jiu-cun LI Bao-lin |
| Institution: | (a Key Laboratory of Medicinal Plant Resource &; Natural Pharmaceutical Chemistry, Ministry of Education, School of Chemistry and Materials Science, Shaanxi Normal University, Xi’an 710062) (b Department of Chemistry, Ankang University, Ankang 725000) |
| Abstract: | By the Friedel-Crafts acylation reaction with aromatic compounds 1a～1h and ethyl oxalyl chloride as the starting materials, eight ethyl arylglyoxylates 2a～2h have been synthesized, and their structures were confirmed by IR, 1H NMR spectra and elemental analyses. The regioselectivity of the reaction was studied by high performance liquid chromatography. This synthetic method provides several advantages such as mild reacting-conditions, simple workup procedures and high yields. |
| Keywords: | ethyl arylglyoxylate acylation reaction synthesis |
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