7,15-Diazadispiro[5.1.5.3]hexadecan und Derivate, 1. Mitt.: Darstellung der Grundkörper

As starting materials for theoretical and pharmacological studies 7,15-diazadispiro5.1.5.3]hexadecane (1), its 14-imino-(2) and 14-oxo-derivative (3) were prepared. Reduction of bis-(1-cyanocyclohexyl)-amine (4) withLAH leads to a mixture of1 and2. For the exclusive preparation of1, 4 is treated with conc. H₂SO₄ to yield the corresponding 14,16-dioxohexadecane, which is reduced to1 withLAH. The preparation of3 is effected by acid hydrolysis of acetylated2.