| Asymmetric Total Synthesis of a Diastereisomer A of Tuxpanolide |
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| 作者姓名： | WANG Jin-Xin
ZHANG Chao-Xin
LI Ying |
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| 作者单位： | WANG,Jin-Xin（State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzho 730000;Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009）
ZHANG,Chao-Xin（State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzho 730000）
LI,Ying（State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzho 730000） |
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| 摘 要： | α-Alkylidene-β-hydroxy butyrolactones have been attractive and challenging targets for organic synthesis in various laboratories because that not only they are rich in skeletal diversity and stereochemistry complexity but also many of them possess quite intriguing and wide biological activities.1] A novel class of the phytane-type diterpenoid named Tuxpanolide, bearing α-alkylidene-β-hydroxy-γ-butyrolactone skeleton, was isolated from Perymenium hintonii in Central Mexico by Maldonado and co-wokers in 1998.2] Now we firstly report the efficient strategy of the stereocontrolled total synthesis of a diastereisomer A of Tuxpanolide.
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Asymmetric Total Synthesis of a Diastereisomer A of Tuxpanolide |
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| WANG,Jin-Xin,ZHANG,Chao-Xin,LI,Ying.Asymmetric Total Synthesis of a Diastereisomer A of Tuxpanolide[J].Chinese Journal of Organic Chemistry,2004,24(Z1):149. |
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| Authors: | WANG Jin-Xin ZHANG Chao-Xin LI Ying |
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| Abstract: | α-Alkylidene-β-hydroxy butyrolactones have been attractive and challenging targets for organic synthesis in various laboratories because that not only they are rich in skeletal diversity and stereochemistry complexity but also many of them possess quite intriguing and wide biological activities.1] A novel class of the phytane-type diterpenoid named Tuxpanolide, bearing α-alkylidene-β-hydroxy-γ-butyrolactone skeleton, was isolated from Perymenium hintonii in Central Mexico by Maldonado and co-wokers in 1998.2] Now we firstly report the efficient strategy of the stereocontrolled total synthesis of a diastereisomer A of Tuxpanolide. |
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