Topical application of solubilized Reseda luteola extract reduces ultraviolet B-induced inflammation in vivo |
| |
Authors: | F. Casetti, W. Jung, U. W lfle, J. Reuter, K. Neumann, B. Gilb, A. W hling, S. Wagner, I. Merfort,C.M. Schempp |
| |
Affiliation: | aCompetence Center skintegral, University Medical Center Freiburg, Germany;bInstitute of Medical Biometry, Charité, Humboldt University Berlin, Germany;cHWI Analytik, Rheinzabern, Germany;dNIG Nahrungs- Ingenieurtechnik, Magdeburg, Germany;eInstitute of Pharmaceutical Sciences, Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, Germany |
| |
Abstract: | We investigated the skin tolerance and anti-inflammatory potential of a nanoparticular solubilisate of a luteolin-rich Reseda extract (s-RE) in two independent studies in vivo. Reseda luteola extract containing 40% flavonoids was solubilized with polysorbate, resulting in product micelles with a diameter of 10 (±1.5) nm. Standardized inflammation was induced by irradiating test areas on the back of healthy volunteers with defined doses of ultraviolet B (UVB). In the first study different concentrations of s-RE were tested in 10 volunteers to evaluate dose-dependency of anti-inflammatory effects of s-RE. In the second randomized, double-blind, placebo-controlled study a defined concentration of s-RE (2.5% w/w) was tested in 40 volunteers in comparison to the vehicle (glycerol) and hydrocortisone (1% w/w). s-RE dose-dependently reduced UVB-induced erythema when applied 30 min before irradiation. To a lesser extent, topical application of s-RE after irradiation also reduced UVB-induced erythema. s-RE was as effective as hydrocortisone, whereas the vehicle had no effect. Occlusive application of s-RE on non-irradiated test sites did not cause any skin irritation. Due to excellent skin tolerance combined with potent anti-inflammatory properties s-RE bears potential especially for the prevention but also for the treatment of inflammatory skin conditions such as UV-induced erythema. |
| |
Keywords: | Reseda luteola L. Luteolin Micelle Minimal erythema dose Nanoparticles Skin inflammation |
本文献已被 ScienceDirect 等数据库收录! |
|