Organocatalytic cascade reactions based on push-pull dienamine platform: synthesis of highly substituted anilines |
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| Authors: | Ramachary Dhevalapally B Ramakumar Kinthada Narayana Vidadala V |
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| Institution: | School of Chemistry, University of Hyderabad, Central University (PO), Hyderabad 500 046, India. ramsc@uohyd.ernet.in |
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| Abstract: | A practical and novel one-pot organocatalytic selective process for the cascade synthesis of highly substituted o-hydroxydiarylamines and o-pyrrolidin-1-yldiarylamines is reported. Direct combination of amine-catalyzed cascade Knoevenagel/Michael/aldol condensation/decarboxylation and cascade enamine amination/isoaromatization of alkyl acetoacetates, aldehydes, and nitrosoarenes furnished the highly functionalized anilines with high yields. |
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