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Specific detection and effective inhibition of a single bacterial species in situ using peptide mineralized Au cluster probes
Authors:Xiangchun Zhang  Li Liu  Ru Liu  Jing Wang  Xuhu Hu  Qing Yuan  Juanjuan Guo  Gengmei Xing  Yuliang Zhao  Xueyun Gao
Abstract:Increasingly serious microbial infections call for the development of new simpler methods for the precise diagnosis and specific inhibition of such pathogens. In this work, a peptide mineralized Au cluster probe was applied as a new simplified strategy to both recognize and inhibit a single bacteria species of Staphylococcus aureus(S. aureus) simultaneously. The probes are composed of peptides and Au clusters. Moreover, the peptides specifically target S. aureus cells and the Au clusters provide fluorescent imaging and have an antibacterial effect. These new probes enable the simultaneous specific detection and effective destruction S. aureus cells in situ.
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