Grafting miniature DNA binding proteins |
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Authors: | Pflum Mary Kay H |
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Institution: | Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA. |
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Abstract: | Miniature proteins serve as leads for biological and medicinal applications by positioning all amino acids necessary for biomolecular recognition on a compact protein structure. Protein grafting was recently used to create miniature helical proteins with high DNA binding affinity and specificity. |
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