Investigation of the Nucleophilic Rearrangement of 2-(Cyanomethyl)-1,4,6-trimethylpyrimidinium Iodide Into 4,6-Dimethyl-2-methylaminonicotinic Acid Nitrile |
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Authors: | G G Danagulyan L G Sahakyan D A Tadevosyan |
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Institution: | (1) Institute of Organic Chemistry, National Academy of Sciences (NAN) of the Republic of Armenia, Erevan, 375094 |
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Abstract: | 2-(Cyanomethyl)-1,4,6-trimethylpyrimidinium iodide is rearranged into 4,6-dimethyl-2-methylaminonicotinic acid nitrile by interaction with alcoholic solutions of sodium ethylate, methylamine, and also glycine and -alanine ethyl esters. This conversion was also observed for the first time for pyrimidinium salts during the process of recording 1H NMR spectra in CD3OD solution containing CD3ONa. After the rearrangement deuterium exchange of the protons of the pyridine ring methyl groups was noted spectrally. It was demonstrated experimentally that for carrying out and completing the recyclization a quantity of nucleophilic reagent must convert the molar equivalent quantity of pyridinium salt. |
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Keywords: | 2-alkylaminonicotinonitrile pyrimidinium salt deuterium exchange Kost– Sagitullin nucleophilic rearrangement |
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