Isokibdelones: novel heterocyclic polyketides from a Kibdelosporangium sp |
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Authors: | Ratnayake Ranjala Lacey Ernest Tennant Shaun Gill Jennifer H Capon Robert J |
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Affiliation: | Centre for Molecular Biodiversity, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia. |
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Abstract: | [Structure: see text] The isokibdelones are an unprecedented family of polyketides produced by an Australian isolate of a rare actinomycete, Kibdelosporangium sp. The structures of the isokibdelones were assigned by spectroscopic analysis and chemical interconversion. A proposed biosynthesis requires a novel molecular twist that generates an unprecedented heterocyclic system and differentiates the isokibdelones from their kibdelone co-metabolites. SAR analysis on the isokibdelones further defines the anticancer pharmacophore of these novel polyketides. |
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