Nanotube confinement denatures protein helices |
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Authors: | Sorin Eric J Pande Vijay S |
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Institution: | Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. |
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Abstract: | In striking contrast to simple polymer physics theory, which does not account for solvent effects, we find that physical confinement of solvated biopolymers decreases solvent entropy, which in turn leads to a reduction in the organized structural content of the polymer. Since our theory is based on a fundamental property of water-protein statistical mechanics, we expect it to have broad implications in many biological and material science contexts. |
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